Type 2 diabetes (T2D) is a multifaceted and heterogeneous syndrome associated with complications such as hypertension, coronary artery disease, and notably, breast cancer (BC). The connection between T2D and BC is established through processes that involve insulin resistance, inflammation and other factors. Despite this comprehension the specific cellular and molecular mechanisms linking T2D to BC, especially through microRNAs (miRNAs), remain elusive. miRNAs are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological processes. However, the signaling pathways and biological processes regulated by miRNAs that are associated with T2D and BC have not yet been elucidated. This review aims to identify dysregulated miRNAs in both T2D and BC, exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.
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机译：2 型糖尿病 （T2D） 是一种多方面和异质性综合征，与高血压、冠状动脉疾病，尤其是乳腺癌 （BC） 等并发症相关。T2D 和 BC 之间的联系是通过涉及胰岛素抵抗、炎症和其他因素的过程建立的。尽管有这种理解，但将 T2D 与 BC 联系起来的特定细胞和分子机制，特别是通过 microRNA （miRNA） 的机制，仍然难以捉摸。miRNA 是转录后水平基因表达的调节因子，具有通过调节各种信号通路和生物过程来调节靶基因的功能。然而，与 T2D 和 BC 相关的 miRNA 调控的信号通路和生物过程尚未阐明。本综述旨在识别 T2D 和 BC 中失调的 miRNA，探索共同促进 BC 发展的潜在信号通路和生物过程。
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