Analysis of correlative risk factors for blood transfusion therapy for extremely low birth weight infants and extreme preterm infants

摘要

Objective: To analyze the related risk factors in blood transfusions for extremely low birth weight infants and extreme preterm infants, and to explore the prevention strategy of anemia. Methods: A total of 60 infants with gestational age < 28 weeks or birth weight < 1000 g admitted to our hospital from January 2017 to December 2020 were retrospectively analyzed. The infants with a birth weight of less than 1000 g were divided into the blood transfusion group and the non-blood transfusion group according to whether they received a blood transfusion. The general health situation, disease occurrence and treatment measures during hospitalization were compared between the two groups, and the risk factors of blood transfusion were analyzed. Results: There were significant differences in maternal anemia during pregnancy, birth weight, gestational age, hemoglobin and hematocrit at birth, blood collection within 2 weeks after birth, length of hospital stay, bronchopulmonary dysplasia and patent ductus arteriosus between the transfusion group and the non-transfusion group (P < 0.05). Multivariate logistic regression analysis and ROC curve analysis showed that the younger the gestational age (OR=0.385, 95% CI: 0.212~0.705, P=0.002), the lower the birth weight (OR=1.004, 95% CI: 0.967~0.998, P=0.001), the longer the hospitalization time (OR=2.178, 95% CI: 1.172~4.049, P=0.014) and a larger blood collection within 2 weeks after birth (OR=1.269, 95% CI: 1.084~1.489, P=0.003) would induce higher the blood transfusion rates. Conclusion: The transfusion indications of extremely low birth weight infants and extreme preterm infants are affected by many factors, among which gestational age, length of hospital stay, blood collection within 2 weeks after birth and birth weight are independent predictors of transfusion. Blood transfusion in extremely low birth weight infants and extreme preterm infants is associated with an increased risk of apnea, neonatal respiratory distress syndrome, bronchopulmonary dysplasia and patent ductus arteriosus.