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Comparison of cannabidiol to citalopram in targeting fear memory in female mice

机译:大麻诱导母老鼠恐惧记忆中的大麻与西普拉姆的比较

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摘要

Trace fear-conditioning produced a tone-associated memory in all treatment groups of female mice. a. Time course of the average percent freezing during memory testing for vehicle-treated mice that received paired conditioning, unpaired conditioning, and non-conditioning. Shaded bars show periods during which the CS was presented. b. Percent freezing was averaged within treatment groups for each conditioning type (black - paired conditioning, dark grey - unpaired conditioning, and light grey - non-conditioned). Auditory-cued memories were validated by statistically comparing freezing levels between mice that received paired versus unpaired conditioning within each treatment group using one-tailed student’s t-tests (*p < 0.05). Comparison of freezing responses between either treatment group that received paired conditioning were not statistically significant (NS) in comparison to control. N = 12 animals per group with standard errors indicated. The timeline for the experiment is shown in the inset above
机译:追踪恐惧调节在雌性小鼠的所有治疗组中产生了语调相关的记忆。一种。在接受配对调节,未配对调节和不调节的载体处理小鼠中冻结期间冻结的平均百分比。阴影条显示CS所呈现的周期。湾每种调节型的治疗组内冻结百分比(黑色配对调节,深灰色 - 未配对调节,浅灰色 - 无条件)。通过统计数据比较在每种治疗组内接受对小鼠与未配对调节的小鼠之间的冰箱水平进行统计验证,使用单尾学生的T检验(* P <0.05)。与对照相比,接受配对调理的任一种治疗组之间的冷冻反应的比较没有统计学意义(NS)。每组N = 12只,标准误差指示。实验的时间表在上面的插图中显示

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