A 71-year-old female patient referred to the author’s orthopedics outpatient clinic with the complaints of pain, purulent discharge and bad odor. Evaluation revealed a defect involving the skin, subcutaneous tissue and bone in the proximal right leg, the appearance of cauliflower and abnormal odor on the skin (Figure 1a). As far as it could be learned from the anamnesis of the patient, she had applied to the doctor about 60 years ago with complaints of pain, redness, swelling under the knee and, as far as understood, treatments such as analgesics, antibiotics, drainage and debridement were applied. The patient and their relatives stated that no results were obtained from the treatments, the sinus tract and defect in the leg increased over time, and pain and discharge increased from time to time. Afterwards, it was learned that the patient's treatment and follow-up were not performed regularly and that she did not go to the hospital for a long time. The patient was hospitalized with a preliminary diagnosis of chronic osteomyelitis as a result of her physical examination and hematological, radiological (Figure 1b, c) and microbiological examinations. The patient and her relatives were informed about her diagnosis and treatment options. Their consent was received. Following the necessary preparations, radical debridement was performed at the first stage (Figure 2a, b), and the defect was filled with antibiotic bone cement (Figure 2c). As a result of microbiological and pathological examination of samples taken from intraoperative bone tissue, the diagnosis of chronic osteomyelitis was confirmed. Squamous cell carcinoma was diagnosed in the pathological examination of soft tissue samples (Figure 3a, b) and bone invasion. The patient underwent scintigraphic screening for other focus and metastasis and was consulted by other relevant specialists. There were no palpable regional lymph nodes. Also, no other focus and/or metastases were detected. Upon the improvement of clinical and laboratory parameters in her follow-up, bone cement removal, debridement, gastrosoleus flap and grafting were performed at the second stage surgery (Figure 4a-c). During the three-year follow-up of the patient, osteomyelitis did not recur and no recurrence or metastasis related to squamous cell carcinoma was observed (Figures 5, 6). But in the fourth year, osteomyelitis recurred.
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