Evolution of a metastatic cancer stem cell (CSC). As a tumour progresses, genetic and epigenetic mechanisms may result in the emergence of a selfrenewing metastatic CSC (mCSC) that expresses different cell surface markers from the CSC that is driving tumorigenesis. This mCSC, through a series of invasive processes that characterize metastasis, enters the blood stream and seeds a secondary tumour in a distinct organ [18]. The copyright of this image belongs to Reference [18].
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