Does multiparametric imaging with 18F-FDG-PET/MRI capture spatial variation in immunohistochemical cancer biomarkers in head and neck squamous cell carcinoma?

摘要

a Photograph of the specimen, the red line indicates that how the specimen was sectioned. b Photograph of the corresponding tumour blocks. From each block, a 4-µm section was obtained and stained with haematoxylin and eosin (H&E) and afterwards digitalised. c All the digitised H&E sections fused into the specimen scan, axial view. d A sagittal view of the pathology fused with the specimen scan. e The specimen scan with the pathology co-registered to the patient FDG-PET/MRI scan. The black circle in panels c–e corresponds to the same area in all three images and is where the core biopsy was taken. S: glandula submandibularis; L: lymph-node metastasis; P: primary tumour. The black contours in d and e illustrates the tumour delineated by the pathologist.