Genetic Variability in the microRNA Binding Sites of BMPR1B TGFBR1 IQGAP1 KRAS SETD8 and RYR3 and Risk of Breast Cancer in Colombian Women

摘要

Genetic variants in microRNA (miR) binding sites affect the regulation of miR-dependent gene expression and have been linked to the risk of a variety of cancers including breast cancer (BC). Most BC risk variants had been identified in women of European and Asian ancestry, but genetic data for Hispanic women are scarce. Here, we investigate the association between six variants in miR binding sites and BC risk in Colombian women.