Spontaneous mutations in the single TTN gene represent high tumor mutation burden

摘要

a Histogram (black line) of the correlation coefficients between the mutation number in each gene and the total mutation count in all genes across the pan-cancer cohort (Pearson correlation test). The scatter plot (blue dots) indicates mutation counts in 20,969 genes from all samples. b Correlation between mutation counts within the TTN gene (TTN-TMB) and TMB by WES (TMB-WES) for the pan-cancer cohort (n = 10,224) (Pearson correlation test). c Correlation coefficients between TTN-TMB and TMB-WES for 33 tumor types (Pearson correlation test). d Correlation coefficients of TTN-TMB and TMB-WES (Y-axis) and total mutation count (mean) (X-axis) for each tumor type. TMB tumor mutation burden, WES whole-exome sequencing.