Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment

摘要

Crosstalk between CSCs and TME components. CSCs secrete a wide variety of soluble factors to recruit and activate stromal cells and reorganize the ECM, as well as to promote angiogenesis, metastasis, hypoxia, immune evasion and tumor progression. These factors also regulate their own maintenance and tumor niche maintenance and the response to different anti-tumor therapies