New Insights into Tumor Heterogeneity: A Case of Solid-Oncocytic Epithelial-Myoepithelial Carcinoma of the Parotid Gland Harboring a HRAS and Heterogeneous Terminating ARID1A Mutation

摘要

Overview of this epithelial-myoepithelial carcinoma. a Shows the lobulated and encapsulated cellular neoplasm. In b a more typical epithelial-myoepithelial differentiation is seen with cystic epithelial structures filled with secretions and focal calcifications. c Depicts the focal prominent fibrous stroma dissecting the epithelial cells, whereas d shows the more solid-oncocytic differentiation, corroborated by p63 and CD117 staining (insets) visualizing the biphasic, epithelial-myoepithelial differentiation. In e intravascular tumor complexes are visible in the capsule region, being surrounded by endothelium (different slide as shown in (a). Scale bar 2.5 mm (a) and 250 μm (b–e)