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Selective Modulation of α5 GABAA Receptors Exacerbates Aberrant Inhibition at Key Hippocampal Neuronal Circuits in APP Mouse Model of Alzheimer’s Disease

机译：α5gabaa受体的选择性调节加剧了阿尔茨海默病的鼠标模型中的关键海马神经元电路中的异常抑制

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期刊名称 Frontiers in Cellular Neuroscience
作者
Alexandra L. Petrache; Archie A. Khan; Martin W. Nicholson; Alessandra Monaco; Martyna Kuta-Siejkowska; Shozeb Haider; Stephen Hilton; Jasmina N. Jovanovic; Afia B. Ali;
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作者单位

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年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 18
原文格式 PDF
正文语种
中图分类神经科学;
关键词

机译：阿尔茨海默病;GABA;

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专利

1. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. [J] . Palop JJ, Chin J, Roberson ED, Neuron . 2007,第5期

机译：阿尔茨海默氏病小鼠模型中异常兴奋性神经元活动和抑制性海马回路的补偿性重塑。
2. The GLP-1 Receptor Agonist Liraglutide Improves Memory Function and Increases Hippocampal CA1 Neuronal Numbers in a Senescence-Accelerated Mouse Model of Alzheimer's Disease [J] . Hansen Henrik H., Fabricius Katrine, Barkholt Pernille, Journal of Alzheimer's disease: JAD . 2015,第4期

机译：GLP-1受体激动剂利拉鲁肽在阿尔茨海默氏病衰老加速小鼠模型中改善记忆功能并增加海马CA1神经元数量
3. Administration of a selective beta 2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer's disease [J] . Branca Caterina, Wisely Elena V., Hartman Lauren K., Neurobiology of Aging: Experimental and Clinical Research . 2014,第12期

机译：选择性的β2肾上腺素能受体拮抗剂的给药加剧了阿尔茨海默氏病小鼠模型的神经病理和认知功能障碍
4. In Vivo and In Silico Evidence: Hippocampal Cholesterol Metabolism Decreases with Aging and Increases with Alzheimers Disease -- Modeling Brain Aging and Disease [C] . Phelix Clyde F., LeBaron Richard G., Roberson Dawnlee J., 11th IEEE International Conference on Data Mining Workshops . 2011

机译：体内和计算机证据：随着年龄的增长，海马胆固醇代谢减少，而阿尔茨海默氏病则增加—模拟脑衰老和疾病
5. The Receptor for Advanced Glycation Endproducts (RAGE) in Microglia Exacerbates Neuroinflammation during Alzheimer’s Disease (AD) and AD-like Murine Models, but is Required for Complex Visual Discrimination [D] . Derk, Julia Jane. 2019

机译：微胶质细胞晚期糖化型肠胃末端产品（RAGE）的受体加剧了阿尔茨海默病（AD）和AD样鼠模型中的神经炎性炎症，但是复杂的视觉鉴别需要
6. Functional Alterations in the Olfactory Neuronal Circuit Occur before Hippocampal Plasticity Deficits in the P301S Mouse Model of Tauopathy: Implications for Early Diagnosis and Translational Research in Alzheimer’s Disease [O] . Abdallah Ahnaou, Daniela Rodriguez-Manrique, Ria Biermans, 2020

机译：嗅觉神经元电路中的功能改变发生在P301S托管病的小鼠模型中的海马可塑性缺陷前发生：对阿尔茨海默病的早期诊断和翻译研究的影响
7. Selective Modulation of α5 GABAA Receptors Exacerbates Aberrant Inhibition at Key Hippocampal Neuronal Circuits in APP Mouse Model of Alzheimer’s Disease [O] . Alexandra L. Petrache, Archie A. Khan, Martin W. Nicholson, 2020

机译：α5gabaa受体的选择性调节加剧了阿尔茨海默病的鼠标模型中的关键海马神经元电路中的异常抑制

Selective Modulation of α5 GABAA Receptors Exacerbates Aberrant Inhibition at Key Hippocampal Neuronal Circuits in APP Mouse Model of Alzheimer’s Disease

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