SUBSTITUTED ARYLPYRAZINES, PHARMACEUTICAL COMPOSITION BASED THEREOF, METHOD FOR MODULATION OF CRF RECEPTORS FUNCTION, METHOD FOR TREATMENT OF CNS-RELATED DISORDERS AND DISEASES, METHOD FOR LOCALIZATION OF CRF RECEPTORS IN TISSUE SPECIMENS, METHOD FOR INHIBITION OF CFR RECEPTOR BINDING WITH CRF1 RECEPTOR, METHOD FOR CHANGING ACTIVITY OF TRANSDUCTION CFR1 RECEPTOR SIGNAL, METHOD FOR MODULATION OF FUNCTION G PROTEIN-COUPLED RECEPTOR

摘要

Arylpyrazine compounds are provided, including arylpyrazines that can bind with high affiity and high selectivity to CRF1 receptors, including human CRF1 receptors. The invention thus includes methods for treatment of disorders and diseases associated with CRF1 receptors, including CNS-related disorders and diseases, particularly affective disorders and diseases, and acute and chronic neurological disorders and diseases.