Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling

摘要

a Representative images of long axis sections of the hearts, and hematoxylin and eosin or Masson’s trichrome stained LV tissue. b LV end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), LV fractional shortening ((LVEDD − LVESD)/LVEDD × 100), intra-ventricular septum diastolic thickness (IVSD), left ventricular posterior wall diastolic thickness (LVPWD). c Peak LVP, LVEDP, dP/dt max of LVP, dP/dt min of LVP, Tau. d LV weight/body weight. e A Kaplan–Meier survival analysis. Values for individual mice are plotted together with mean ± SEM. Parentheses indicate the number of mice. *P < 0.05, **P < 0.01, ***P < 0.001 (one-way ANOVA with post-hoc Tukey’s multiple comparison test).