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Vascular territorial segmentation and volumetric blood flow measurement using dynamic contrast enhanced magnetic resonance angiography of the brain

机译:使用动态对比增强型脑部磁共振血管造影术进行血管区域分割和体积血流量测量

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摘要

This study proposes a method for territorial segmentation and volumetric flow rate (VFR) distribution measurement of cerebral territories based on time-resolved contrast enhanced magnetic-resonance-angiography (MRA). The method uses an iterative region-growing algorithm based on bolus-arrival-time with increased temporal resolution. Eight territories were segmented: (1) right and (2) left internal carotid arteries, including the middle cerebral artery (ICA+MCA), excluding the anterior cerebral arteries (ACA); (3) right and left ACA (R+L-ACA); (4) right and (5) left external carotid arteries (ECA); (6) right and (7) left posterior cerebral arteries (PCA); and (8) vertebrobasilar territory. VFR percentage, relative to the entire brain (rVFR), was measured based on territorial volume as a function of time. Mean rVFR values of fifteen healthy subjects were: ICA+MCA = 23 ± 2%, R + L-ACA = 17 ± 3%, ECA = 4 ± 2%, PCA = 12 ± 2%, and vertebrobasilar territory = 31 ± 4%. Excluding the ECA-rVFR, which is underestimated, these values are comparable to previously reported values. Six subjects were scanned twice, demonstrating comparable and even higher reproducibility than previously reported using phase-contrast, yet with faster scan time (∼1 min). This method was implemented in one patient with MCA occlusion and one with Moyamoya syndrome scanned before and after bypass surgery, demonstrating its clinical potential for quantitative assessment of the degree of occlusion and the effect of surgery.
机译:这项研究提出了一种基于时间分辨的对比增强磁共振血管造影(MRA)的脑区域的领土分割和体积流量(VFR)分布测量方法。该方法使用基于快速到达时间的大剂量到达时间的迭代区域增长算法。分为八个区域:(1)右颈动脉(2)和左颈内动脉(2),包括大脑中动脉(ICA + MCA),不包括前脑动脉(ACA); (3)左右ACA(R + L-ACA); (4)右和(5)左颈外动脉(ECA); (6)右和(7)左后脑动脉(PCA); (8)椎基底基底区域。相对于整个大脑的VFR百分比(rVFR)是根据领土体积随时间变化来衡量的。 15名健康受试者的平均rVFR值为:ICA + MCA = 23±2%,R + L-ACA = 17±3%,ECA = 4±2%,PCA = 12±2%,椎基底区域asi = 31±4 %。除了被低估的ECA-rVFR,这些值与以前报告的值相当。对六名受试者进行了两次扫描,证明其可重复性与以前使用相差报告的结果相当甚至更高,但扫描时间更快(〜1分钟)。该方法适用于一名MCA闭塞患者和一名Moyamoya综合征患者,在旁路手术前后进行了扫描,证明了其在定量评估闭塞程度和手术效果方面的临床潜力。

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