Oncogenic role of lncRNA CRNDE in acute promyelocytic leukemia and NPM1-mutant acute myeloid leukemia

摘要

a–b Heatmap displays the expression values of differentially expressed lncRNAs between APL and non-APL AML (a) or APL and normal bone marrows (b). The RNA-seq data of 29 APL, 350 non-APL AML and 21 normal bone marrows (Normal) were retrieved from the TCGA and Beat AML cohorts. The 102 upregulated and 136 downregulated lncRNAs clearly separate APL from non-APL AML (a). The 183 upregulated and 279 downregulated lncRNAs clearly separate APL from normal bone marrows (b). c Venn diagram shows the overlapped differentially expressed lncRNAs between APL versus non-APL AML (blue) and APL versus normal bone marrows (yellow). Numbers in red represent overlapped lncRNAs upregulated or downregulated in APL. The representative lncRNAs are shown in the table below. d Gene set enrichment analysis (GSEA) plots show enrichment for pathogenesis-related lncRNAs upregulated (upper panel) or downregulated (lower panel) in APL versus normal promyelocytes ({"type":"entrez-geo","attrs":{"text":"GSE12662","term_id":"12662"}}GSE12662). Pros, promyelocytes; NES, normalized enrichment score; FDR q-value, false discovery rate q-value.