Dose response relationship of cumulative anticholinergic exposure with incident dementia: validation study of Korean anticholinergic burden scale

摘要

The layout of research design. 1) In order to minimize the protopathic bias, the first year before index date was excluded. Also, sensitivity analysis was done after excluding the first 4 years before index date. 2) The Korean version anticholinergic burden scale (KABS) and the Anticholinergic Cognitive Burden Scale (ACB) were used as the standard of anticholinergic burden score. 3) For measuring the sedative load, the sedative load model was used; score 2 for primary sedative agents and score 1 for medications having sedation as a prominent side effects. 4) Matching variables: age, sex, and baseline co-morbid diseases including hypertension, dyslipidemia, heart failure, atrial fibrillation, ischemic heart disease, diabetes mellitus, cerebrovascular disease, Parkinson’s disease, depression, anxiety, insomnia, and alcohol disease