Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells

摘要

OTUD3 downregulation is correlated with a poor prognosis in BC patients. a The transcriptional level of OTUD3 in BC tissues compared to that in normal breast tissues. b-c The transcriptional level of OTUD3 in BC patients based on individual cancer stages and major subclasses. d. Correlation scatter plot of OTUD3 mRNA expression and methylation levels in BC patients. e-g Prognostic value of the mRNA levels of OTUD3, p53 and PTEN in BC patients (RFS according to the Kaplan-Meier Plotter). e OTUD3 (213216_s_at). f P53 (201746_at). g PTEN (225363_at)