Novel insights on targeting ferroptosis in cancer therapy

摘要

Sketch of ferroptosis mechanism. The mechanism of ferroptosis in cells. Cys2 that enter the cytoplasm via systemXc− synthesize GSH with glutamate, glycine and cysteine. GPX4 is a kind of GSH-dependent reductase. When GPX4 dysfunction, lipid transforms into lipid ROS with O2 and Fe2+. L-ROS attack intracellular biomolecules and kill the cell