RNA editing of the 5-HT2C receptor in the central nucleus of the amygdala is involved in resilience behavior

摘要

(A) Schematic depiction of the experimental model. The animals began the experimental procedure after two weeks of acclimation and habituation to the home cage and the open field. Baseline response to the three behavioral scenarios was monitored on day 1. Day 7: Exposure to ‘trauma’ (Initial exposure). Day 14: first exposure to the ‘trauma’s’ reminder (‘first reminder’). Day 35: second exposure to the ‘trauma’s reminder (‘second reminder’). Day 56: third exposure to the ‘trauma’s reminder (‘third reminder’). Day 77: fourth exposure to the ‘trauma’s reminder (‘fourth reminder’). (B) Freezing behavior during: exploration, (C) social interaction, and (D) hyperarousal tests. After exposure to trauma and the reminders, susceptible but not resilient animals showed an increase from baseline in freezing behavior, i.e., incubation of fear over time in all three behavioral tests (exploration: *p < 0.05 and ***p < 0.001 susceptible vs. resilient; social interaction: ***p < 0.001 susceptible vs. resilient and hyperarousal: *p < 0.05 and ***p < 0.001 susceptible vs resilient). Data presented as mean ± SEM; n = 26–35 per group. (E–G) Pearson’s product-moment correlation between the following tests: (E) exploration×social interaction, (F) hyperarousal×exploration, and (G) hyperarousal×social interaction (r > 0.33; *p < 0.005).