Adenosine A

摘要

A The selective mGlu5R agonist CHPG induced a long-lasting synaptic depression in the fEPSP recorded in Fmr1 KO mice (n = 4 animals, 7 slices, *p < 0.01 vs. basal and *p < 0.05 vs. WT, Mann-Whitney test), while in WT mice (n = 5 animals, 6 slices) the synaptic transmission recovered completely after the CHPG application. B In the Fmr1 KO mice, the long-lasting effect of CHPG on synaptic depression was prevented by a pre-treatment with the selective A2AR antagonist ZM241385 (n = 3 animals, 4 slices, °p < 0.05 vs. CHPG alone in Fmr1 KO, Mann-Whitney test). C A pre-treatment with the selective A2AR agonist {"type":"entrez-protein","attrs":{"text":"CGS21680","term_id":"878113053","term_text":"CGS21680"}}CGS21680 potentiated CHPG-induced MTD in Fmr1 KO mice (n = 5 animals, 6 slices, §p < 0.05 vs. CGS + CHPG in WT, Mann-Whitney test). D The dot-plot graph summarizes the results. Insets in panels (A–C) show representative fEPSP recordings in correspondence of baseline (1), MTD (2), or late washout (3). Calibration bars: 1 mV, 10 ms.