Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

摘要

A simple method was used to prepare curcumin/silver nanocomposite based chitosan hydrogel. In an alkaline medium, chitosan and chitosan nanocomposite hydrogels were prepared using the physical crosslinking method. The prepared hydrogels were stable for a long period at room temperature. In one step, silver nanoparticles were prepared insitu using silver nitrate solution and curcumin oxide within the hydrogel network formation. In the meantime, curcumin compound served as both a reducing and stabilizing agent. The structure and surface morphology of nanocomposite hydrogels were characterized by FTIR, SEM, and EDX analysis confirmed the formation of silver nanoparticles within the hydrogel network. Moreover, Images of TEM showed a spherical shape of silver nanoparticles with an average size of 2–10 nm within the matrix of the hydrogel. The formation mechanism of nanocomposite based hydrogel was reported. Besides that, the effect of chitosan and silver nitrate concentrations were studied. The swelling capacity of the prepared nanocomposite hydrogels was also performed at different pH of 4, 7, and 9. From the experimental results, the swelling capacity of hydrogels depends on the concentrations of chitosan and silver nitrate. The prepared composite based hydrogel exceeds a higher swelling degree than chitosan hydrogels at low pH. The antibacterial activity of the nanocomposite hydrogels was also examined; the results showed that the prepared nanocomposite hydrogels outperformed the pure chitosan hydrogels. This shows them to be a promising material for the biomedical field as a wound dressing and drug release.