在壳聚糖/1,2-丙二醇凝胶中采用抗坏血酸原位还原硝酸银生成纳米银,进而通过碱液置换得到具有不同纳米银含量的物理交联的纳米银/壳聚糖复合水凝胶.紫外-可见光谱、X射线衍射图谱和低分辨率TEM照片的结果表明,复合水凝胶内形成了分散良好的纳米银.高分辨率TEM照片结果表明纳米银的直径在20～50nm之间,但其结晶状态并不均一.抗菌性实验证明,纳米银/壳聚糖复合水凝胶对大肠杆菌和金黄色葡萄球菌均有抗菌效果.%Nano-silver particles were in situ prepared by reducing silver nitrate with ascorbic acid in chitosan/1, 2-propylene glycol gel, and then nano-silver/chitosan composite physical hydrogels with different content of nano-silver were obtained by replacing 1,2-propanediol with alkaline solution. UV-visible spectra, XRD diffraction patterns and low resolution TEM images show that nano-silver particles with a good dispersion were formed in the composite hydrogels. High resolution TEM images indicate that the nano-silver particles were between 20-50nm in diameter, but its crystalline state was not uniform. Antimicrobial experiments illustrate the antibacterial properties of the nano-silver/chitosan composite hydrogel to Escherichiacoli and Staphylococcus aureus.
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