Mammalian expression of virus-like particles as a proof of principle for next generation polio vaccines

摘要

a Schematic representation of the poliovirus genome highlighting the P1 region and individual capsid protein subunits generated from proteolytic processing by 3CD. b Format of the three separate expression cassettes used to test co-expression of P1 and 3CD* in PV1 wt (FMDV-2A), PV2 wt (HIV-FS) and PV3 wt (PV-IRES). Image was created using SnapGene® software (from GSL Biotech; available at snapgene.com).