Ethyl acetate Fraction of Garcinia Mangostana L Rind Study as Antimalaria and Antioxidant in Plasmodium berghei Inoculated Mice

摘要

BACKGROUND:Drug resistance to malaria is still a problem in various regions, and there have even been developments in resistance to the ACTs (artemisinin-based combination therapies) as standard antimalarial drugs included to artemisinin’s partner drugs. Ethyl acetate fraction of G. mangostana L rind, containing xanthones as an antioxidant, has antimalarial activity in vitro which has a synergistic effect with artemisinin. That’s why the activities of this fraction are needed to be studied in vivo.