A role for bronchial epithelial autotaxin in ventilator-induced lung injury

摘要

Increased ATX concentrations in the BALFs and plasma of ventilated mice. a Graphic representation of the experimental groups studied. b BALF ATX concentrations were measured using an ELISA assay. c ATX concentrations in plasma were determined by ELISA. d, e ATX activity in BALFs and in plasma, respectively, was measured using a modified Amplex Red PLD activity kit. n = 5 mice per group. Data are expressed as medians with interquartile range (*statistically significant differences, P < 0.05) LTV low tidal volume, HTV high tidal volume, ATX autotaxin, BALF bronchoalveolar lavage fluid, PLD phospholipase D