Making ends meet in class switch recombination

摘要

a AID initiates DSBs in S regions of IgH. Loop extrusion is proposed to bring donor and acceptor S regions into close proximity. Deletional recombination generates a functional product while the intra DNA is looped out. ERCC6L2 promotes this productive pathway of deletional CSR. b Schematic diagram of the domain structure of ERCC6L2.