Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer

摘要

The identification and validation of strategies to individualise therapy of patients with head and neck squamous cell carcinoma require cellular and animal models that accurately represent the complex microenvironment in which human tumours grow. Recently, patient-derived xenograft and organoid models of head and neck squamous cell carcinoma have been established that recapitulate the morphology, genetics and response to therapy of the human tumours they originated from. In this review, we discuss the development of patient-derived xenograft and organoid models of head and neck squamous cell carcinoma and describe their ability to predict clinical response to therapy. We focus on the utility of these tools to enable greater precision of both approved and experimental medicines through individualised therapeutic approaches.