In Vivo Hepatoprotective and Nephroprotective Activity of Acylated Iridoid Glycosides from

摘要

Chronic liver disease is a major life-threating problem worldwide. Deaths due to liver disease constituted 2.4% of total deaths globally in 2017. Yet most of the available drugs for improving liver conditions are of natural origin. More research is necessary to discover agents that are more effective. Previously, the extract of Scrophularia hypericifolia showed promising protection of liver and kidney tissues against induced toxicity in experimental animals. The current phytochemical study aimed to identify the active molecules in the extract. Nine iridoid glycoside derivatives were identified from the plant extract, including four new compounds after extensive chromatographic purification. The structures were identified by applying various spectroscopic methods. Biological evaluation for protective effect on liver and kidney tissues was conducted on compounds isolated with a high enough yield. Serum and tissue parameters as well as histopathological studies were conducted for efficacy evaluation. Two of the new compounds showed the best protection of liver and kidney tissues as indicated by the studied parameters. These findings indicated that natural products could provide solutions to health problems. The role of nutraceuticals in managing liver problems is a promising field for further studies.