Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus

摘要

Ten weeks of metformin treatment in late middle age is efficacious for improving cognitive function in the old age. Improved cognitive function following metformin treatment was linked with antiinflammatory effects, the activation of adenosine monophosphate‐activated protein kinase (AMPK), the mammalian target of rapamycin (mTOR) signaling, and increased autophagy in the aged hippocampus. The results suggest that metformin therapy in middle age leads to better cognitive function in old age.