Safety and Biocompatibility of Aflibercept-Loaded Microsphere Thermo-Responsive Hydrogel Drug Delivery System in a Nonhuman Primate Model

机译：非洲灵长类动物模型中AFLibercept-Loaded Microce热响应水凝胶药物输送系统的安全性和生物相容性

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摘要

To evaluate the safety and tolerability of a microsphere thermo-responsive hydrogel drug delivery system (DDS) loaded with aflibercept in a nonhuman primate model.

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期刊名称 Translational Vision Science Technology
作者
Soohyun Kim; Jennifer J. Kang-Mieler; Wenqiang Liu; Zhe Wang; Glenn Yiu; Leandro B. C. Teixeira; William F. Mieler; Sara M. Thomasy;
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年(卷),期 -1(9),3
年度 -1
页码 -1
总页数 14
原文格式 PDF
正文语种
中图分类眼科学;
关键词
anti-VEGF; thermo-responsive hydrogel; aflibercept; nonhuman primate; intravitreal injection; controlled drug delivery;

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专利

1. Aflibercept-loaded Microsphere-hydrogel Drug Delivery System in a Nonhuman Primate Model [J] . Kang-Mieler Jennifer J., Kim Soohyun, Wang Zhe, Investigative ophthalmology & visual science . 2018,第9期

机译：令人毛骨悚然的载荷的微球 - 水凝胶药物递送系统在非人类气密模型中
2. Aflibercept-loaded Microsphere-hydrogel Drug Delivery System in a Nonhuman Primate Model [J] . Kang-Mieler Jennifer J., Kim Soohyun, Wang Zhe, Investigative ophthalmology & visual science . 2018,第9期

机译：令人毛骨悚然的载荷的微球 - 水凝胶药物递送系统在非人类气密模型中
3. Efficacy of a Biodegradable Aflibercept-loaded Microsphere-Hydrogel Drug Delivery System in a Laser-induced Choroidal Neovascularization Rat Model [J] . Liu Wenqiang, Puskar Anessa, Mieler William F., Investigative ophthalmology & visual science . 2018,第9期

机译：激光诱导的脉络膜新生血管化大鼠模型中生物降解的AFLibercept-Handlog-hycle-Hydle-Hymergel药物递送系统的功效
4. Self-Assembling MMP-2 Cleavable Hydrogel Drug Delivery Systems; Neural Tissue Biocompatibility and Response [C] . K. Koss, M. Churchward, K. Todd, Society for Biomaterials annual meeting and exposition . 2015

机译：自组装的MMP-2可裂解水凝胶给药系统;神经组织生物相容性和反应
5. A Biodegradable Microsphere-Hydrogel Ocular Drug Delivery System for Treatment of Choroidal Neovascularization [D] . Liu, Wenqiang . 2020

机译：一种可生物降解的微球 - 水凝胶眼药递送系统，用于治疗脉络膜新生血管
6. Chitosan temperature-sensitive gel loaded with drug microspheres has excellent effectiveness biocompatibility and safety as an ophthalmic drug delivery system [O] . Xiaoying Kong, Wenhua Xu, Cuiping Zhang, -1

机译：载有药物微球的壳聚糖热敏凝胶作为眼科给药系统具有优异的功效生物相容性和安全性
7. pH/Thermo-Responsive Grafted Alginate-Based SiO2 Hybrid Nanocarrier/Hydrogel Drug Delivery Systems [O] . Nikolaos Theodorakis, Sofia-Falia Saravanou, Nikoleta-Paraskevi Kouli, 2021

机译：基于pH /热响应接枝藻酸盐的SiO2杂交纳米载体/水凝胶药物递送系统

Safety and Biocompatibility of Aflibercept-Loaded Microsphere Thermo-Responsive Hydrogel Drug Delivery System in a Nonhuman Primate Model

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