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Protocol: Impact of incremental versus conventional initiation of haemodialysis on residual kidney function: study protocol for a multicentre feasibility randomised controlled trial

机译:协议:增量对血液透析对血液透析的影响对残余肾功能:多期可行性随机对照试验的研究方案

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摘要

Preserving residual kidney function (RKF) may be beneficial to patients on haemodialysis (HD) and it has been proposed that commencing dialysis incrementally rather than three times a week may preserve RKF. In Incremental HD, target dose includes a contribution from RKF, which is added to HD dose, allowing individualisation of the HD prescription. We will conduct a feasibility randomised controlled trial (RCT) comparing incremental HD and conventional three times weekly treatments in incident HD patients. The study is designed also to provide pilot data to allow determination of effect size to power a definitive study.
机译:保存残留的肾功能(RKF)可能对血液透析(HD)的患者有益,并且已经提出了每周逐步开始透析而不是三次可以保护RKF。在增量HD中,靶剂剂量包括RKF的贡献,其被添加到HD剂量,允许HD处方的个体化。我们将进行可行性随机对照试验(RCT)比较来自事件高清患者的增量HD和常规三次治疗。该研究还设计用于提供导频数据,以允许确定效果大小以为最终的研究提供动力。

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