An intensive education program for caregivers ameliorates anxietydepression and quality of life in patients with drug-resistant temporal lobeepilepsy and mesial temporal sclerosis who underwentcortico-amygdalohippocampectomy

摘要

This study aimed to investigate the effect of a caregiver intensive educationprogram (CIEP) on anxiety, depression, and quality of life (QOL) in patientswith drug-resistant temporal lobe epilepsy and mesial temporal sclerosis(TLE-MTS) who underwent cortico-amygdalohippocampectomy (CAH). Ninety patientswith drug-resistant TLE-MTS who underwent CAH and their caregivers wererecruited and randomly allocated to the CIEP group or control group as 1:1ratio. Caregivers received the CIEP program or routine guidance/education(control group). Anxiety/depression and QOL in patients at month (M)0, M1, M3,and M6 were assessed by the Hospital Anxiety and Depression Scale (HADS) scaleand the QOL in Epilepsy Inventory-31 (QOLIE-31), respectively. Treatmentefficacy at M6 was assessed by Engel classification. The HADS-anxiety score atM3 (P=0.049) and M6 (P=0.028), HADS-anxiety score change (M6-M0) (P=0.001),percentage of anxiety patients at M6 (P=0.025), and anxiety severity at M6(P=0.011) were all decreased in the CIEP group compared with the control group.The HADS-depression score at M6 (P=0.033) and HADS-depression score change(M6-M0) (P=0.022) were reduced, while percentage of depression patients at M6(P=0.099) and depression severity at M6 (P=0.553) showed no difference in theCIEP group compared with the control group. The QOLIE-31 score at M6 (P=0.043)and QOLIE-31 score change (M6-M0) (P=0.010) were both elevated in the CIEP groupcompared with the control group. In conclusion, CIEP for caregivers contributedto the recovery of anxiety and depression as well as the improvement of QOL inpatients with drug-resistant TLE-MTS who underwent CAH.