首页> 美国卫生研究院文献>Journal of Clinical Oncology >Phase I Study of DSTP3086S an Antibody-Drug Conjugate Targeting Six-Transmembrane Epithelial Antigen of Prostate 1 in Metastatic Castration-Resistant Prostate Cancer

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Phase I Study of DSTP3086S an Antibody-Drug Conjugate Targeting Six-Transmembrane Epithelial Antigen of Prostate 1 in Metastatic Castration-Resistant Prostate Cancer

机译：DSTP3086S（靶向前列腺1的六跨膜上皮抗原的抗体-药物偶联物）在转移性去势抵抗性前列腺癌中的I期研究

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Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is highly expressed in prostate cancers. DSTP3086S is a humanized immunoglobulin G1 anti-STEAP1 monoclonal antibody linked to the potent antimitotic agent monomethyl auristatin E. This study evaluated the safety and activity of DSTP3086S in patients with metastatic castration-resistant prostate cancer.

机译：前列腺1的六跨膜上皮抗原（STEAP1）在前列腺癌中高度表达。 DSTP3086S是人源化免疫球蛋白G1抗STEAP1单克隆抗体，与有效的抗有丝分裂剂Monomethyl auristatin E连接。这项研究评估了DSTP3086S在转移性去势抵抗性前列腺癌患者中的安全性和活性。

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期刊名称 Journal of Clinical Oncology
作者
Daniel C. Danila; Russell Z. Szmulewitz; Ulka Vaishampayan; Celestia S. Higano; Ari D. Baron; Houston N. Gilbert; Flavia Brunstein; Marija Milojic-Blair; Bei Wang; Omar Kabbarah; Michael Mamounas; Bernard M. Fine; Daniel J. Maslyar; Alexander Ungewickell; Howard I. Scher;
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年(卷),期 -1(37),36
年度 -1
页码 -1
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学 ;
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专利

1. Phase I Study of DSTP3086S, an Antibody-Drug Conjugate Targeting Six-Transmembrane Epithelial Antigen of Prostate 1, in Metastatic Castration-Resistant Prostate Cancer [J] . Danila Daniel C., Szmulewitz Russell Z., Vaishampayan Ulka, Journal of Clinical Oncology . 2019 ,第36期

机译：I阶段DSTP3086S研究，靶向前列腺癌前列腺癌的六跨膜上皮抗原靶向六跨膜上皮抗原的抗体 - 药物缀合物
2. Phase 1/2 multiple ascending dose trial of the prostate-specific membrane antigen-targeted antibody drug conjugate MLN2704 in metastatic castration-resistant prostate cancer [J] . Milowsky Matthew I., Galsky Matthew D., Morris Michael J., Urologic oncology . 2016 ,第12期

机译：前列腺特异性膜抗原靶向抗体药物偶联物MLN2704在转移性去势抵抗性前列腺癌中的1/2期多次递增剂量试验
3. 340?Phase 1 study of AMG 160, a half-life extended BiTE? (bispecific T-cell engager) therapy targeting prostate-specific membrane antigen, in patients with metastatic castration-resistant prostate cancer [J] . Tanya Dorff, Matthew Rettig, Jean-Pascal Machiels, Journal for ImmunoTherapy of Cancer . 2020 ,第Suppla3期

机译：340？相1研究AMG 160，半衰期延伸咬合？（双特异性T细胞录音机）靶向前列腺特异性膜抗原的治疗，抗转移性阉割的前列腺癌患者
4. Metastatic Hormone-Sensitive and Castration-Resistant Prostate Cancer: A Decade of Progress and Ongoing Discoveries [C] . Leonel Hernez-Aya, Maha Hussain Genitourinary Cancers Symposium. . 2014

机译：转移激素敏感和阉割的前列腺癌：进步和持续发现的十年
5. Biochemical characterization of the six-transmembrane epithelial antigen of the prostate family of metalloreductases [D] . Kleven, Mark Daniel 2015

机译：金属还原酶前列腺家族六跨膜上皮抗原的生化特性
6. Phase 1/2 Multiple Ascending Dose Trial of the Prostate-Specific Membrane Antigen (PSMA)-Targeted Antibody Drug Conjugate MLN2704 in Metastatic Castration-Resistant Prostate Cancer [O] . Matthew I. Milowsky, Matthew D. Galsky, Michael J. Morris, -1

机译：前列腺特异性膜抗原（PSMA）靶向抗体药物偶联物MLN2704在转移性去势抵抗性前列腺癌中的1/2期多次递增剂量试验
7. Ipilimumab and a poxviral vaccine targeting prostate-specific antigen in metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial [O] . Ravi A Madan, Mahsa Mohebtash, Philip M Arlen, 2012

机译：IPILIMIMAB和毒性疫苗靶向前列腺特异性抗原在转移性阉割前列腺癌中：一个剂量1剂量升级试验

Phase I Study of DSTP3086S an Antibody-Drug Conjugate Targeting Six-Transmembrane Epithelial Antigen of Prostate 1 in Metastatic Castration-Resistant Prostate Cancer

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