Zearalenone (ZEN) in Livestock and Poultry: Dose Toxicokinetics Toxicity and Estrogenicity

摘要

One of the concerns when using grain ingredients in feed formulation for livestock and poultry diets is mycotoxin contamination. Aflatoxin, fumonisin, ochratoxin, trichothecene (deoxynivalenol, T-2 and HT-2) and zearalenone (ZEN) are mycotoxins that have been frequently reported in animal feed. ZEN, which has raised additional concern due to its estrogenic response in animals, is mainly produced by ( ), , , , and , and often co-occurs with deoxynivalenol in grains. The commonly elaborated derivatives of ZEN are α-zearalenol, β-zearalenol, zearalanone, α-zearalanol, and β-zearalanol. Other modified and masked forms of ZEN (including the extractable conjugated and non-extractable bound derivatives of ZEN) have also been quantified. In this review, common dose of ZEN in animal feed was summarized. The absorption rate, distribution (“carry-over”), major metabolites, toxicity and estrogenicity of ZEN related to poultry, swine and ruminants are discussed.