Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells

摘要

Quantitative differences between naive and follicular helper T cell open chromatin landscapes. A total of 91,222 OCR were used as reference for differential analysis of genome accessibility. The number of statistically up- (green) or down- (red) regulated OCR in TFH compared to naive (FDR  1 or b, GSEA enrichment analysis of genes with differential promoter accessibility at promoter regions. The log2 fold change in promoter accessibility of genes upregulated ( ) or downregulated ( ) in TFH vs. naive was used to generate a pre-ranked list for comparison to differentially expressed genes.