Enhanced inhibition of foot-and-mouth disease virus by combinations of porcine interferon-α and antiviral agents

机译：猪干扰素-α和抗病毒剂联合使用可增强对口蹄疫病毒的抑制作用

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摘要

► We measured EC and CC of the five well-known or potential antiviral agents. ► The antiviral effect against of 6-Azauridine was demonstrated. ► We tested the combination effects of the pairs of antiviral agents. ► Enhanced antiviral effect of Ad-porcine IFN-α with Ribavirin was demonstrated. ► Enhanced antiviral effect of Ad-porcine IFN-α and Ad-siRNA was demonstrated.

机译：►我们测量了五种著名或潜在的抗病毒药物的EC和CC。 ►证明了对6-氮杂尿嘧啶的抗病毒作用。 ►我们测试了抗病毒剂对的组合作用。 ►证实了Ad-猪IFN-α与利巴韦林的抗病毒作用增强。 ►证实了Ad-猪IFN-α和Ad-siRNA的抗病毒作用增强。

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期刊名称 Elsevier Public Health Emergency Collection
作者
Su-Mi Kim; Jong-Hyeon Park; Kwang-Nyeong Lee; Se-Kyung Kim; Young-Joon Ko; Hyang-Sim Lee; In-Soo Cho;
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作者单位

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年(卷),期 -1(96),2
年度 -1
页码 -1
总页数 9
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
CPE; cytopathic effect; CC50; cytotoxic concentration required to reduce cell viability by 50; EC50; effective concentration required to reduce virus-induced cytopathogenicity by 50; FMD; foot-and-mouth disease; FMDV; foot-and-mouth disease virus; Guanidine-HCl; Guanidine hydrochloride; IFN; interferon; IP; intraperitoneal; SD; standard deviation; siRNA; small interference RNA; shRNA; short hairpin RNA; RNAi; RNA interference; RT-PCR; reverse transcriptase polymerase chain reaction; TCID;

机译：CPE;细胞病变作用;CC50;使细胞活力降低50％所需的细胞毒性浓度;EC50;将病毒诱导的细胞致病性降低50％所需的有效浓度;口蹄疫;口蹄疫;口蹄疫;口蹄疫病毒;口蹄疫盐酸胍;盐酸胍;干扰素;干扰素;IP;腹膜内;SD;标准差;siRNA;小干扰RNA;shRNA;短发夹RNA;RNAi;RNA干扰;RT-PCR;逆转录聚合酶链反应;TCID;

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专利

1. Enhanced inhibition of foot-and-mouth disease virus by combinations of porcine interferon-α and antiviral agents [J] . Antiviral Research . 2012,第2期

机译：猪干扰素-α和抗病毒剂联合使用可增强对口蹄疫病毒的抑制作用
2. A recombinant adenovirus bicistronically expressing porcine interferon-alpha and interferon-gamma enhances antiviral effects against foot-and-mouth disease virus [J] . Su-Mi Kim, Se-Kyung Kim, Jong-Hyeon Park, Antiviral Research . 2014,第Null期

机译：双顺反子表达猪α-干扰素和γ-干扰素的重组腺病毒可增强针对口蹄疫病毒的抗病毒作用
3. Expression of porcine Mx1 with FMDV IRES enhances the antiviral activity against foot-and-mouth disease virus in PK-15 cells [J] . Yuan Bing, Fang Hui, Shen Chao, Archives of virology . 2015,第8期

机译：带有FMDV IRES的猪Mx1的表达增强了PK-15细胞中针对口蹄疫病毒的抗病毒活性
4. Inhibition of Foot-and-Mouth Disease Virus Replication by the Bovine Mx1 Protein [C] . Cai Kuojun, Qiao Jun, Meng Qingling, 16th International congress on animal hygiene : animal hygiene, health and welfare as corner stones of sustainable animal production . 2013

机译：牛Mx1蛋白抑制口蹄疫病毒复制
5. Porcine mucosal vaccination against foot-and-mouth disease virus. [D] . Barrette, Roger William, II. 2007

机译：针对口蹄疫病毒的猪粘膜疫苗接种。
6. Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type I and II Porcine Interferons [O] . Mauro Pires Moraes, Teresa de los Santos, Marla Koster, 2007

机译：通过I型和II型猪干扰素的结合增强对口蹄疫病毒的抗病毒活性
7. Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type I and II Porcine Interferons▿ [O] . Moraes, Mauro Pires, de los Santos, Teresa, Koster, Marla, 2007

机译：通过I型和II型猪干扰素联合使用增强对口蹄疫病毒的抗病毒活性

Enhanced inhibition of foot-and-mouth disease virus by combinations of porcine interferon-α and antiviral agents

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