Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides

摘要

The enantiomerically pure carbocyclic purine and pyrimidine C-nucleosides – were synthesized via the key intermediate, 2,3-(isopropylidenedioxy)-4-(trityloxymethyl)-4-cyclopenten-1-ol ( ), which was prepared from -ribose in eight steps. Synthesized compounds were evaluated as potential antiviral agents against HIV, SARSCoV, Punta Toro, West Nile, and Cowpox viruses. However, only 9-deazaneplanocin A ( ) exhibited moderate anti-HIV activity.