Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma

摘要

Histone deacetylases ( s) are commonly dysregulated in cancer and represent promising therapeutic targets. However, global inhibitors have shown limited efficacy in the treatment of solid tumours, including hepatocellular carcinoma ( ). In this study, we investigated the therapeutic effect of selectively inhibiting 1 and 2 in .