Tetraploid complementation proves pluripotency of induced pluripotent stem cells derived from adipose tissue

摘要

Recently, pluripotency of induced pluripotent stem ( ) cells has been displayed after producing adult mice, in tetraploid complementation assays. These studies lead us to the last piece of the puzzle for reprogramming somatic cells into fully pluripotent cells which function as embryonic stem cells in most applications. However, in all of previous studies, skin fibroblasts were used as the starting population for reprogramming, raising questions as to whether the pluripotency of the cells was dependent on the particular starting cell type.