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Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

机译：阿魏酸哌嗪预处理对甲氨蝶呤致肾损伤模型大鼠甲氨蝶呤药代动力学参数的影响

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摘要

A HPLC-MS method had been developed and applied to investigate the influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate. The changes in the pharmacokinetic behavior indicated that the pretreatment of piperazine ferulate might exert the protective effect on methotrexate-induced renal injury.

机译：开发了一种HPLC-MS方法，用于研究阿魏酸哌嗪预处理对甲氨蝶呤药代动力学参数的影响。药代动力学行为的变化表明阿魏酸哌嗪的预处理可能对甲氨蝶呤致肾损伤具有保护作用。

著录项

期刊名称 Asian Journal of Pharmaceutical Sciences
作者
Huiyan Shi; Chenzhi Hou; Liqiang Gu; Zhe Wei; Hang Xing; Meiyu Zhang; Shixiao Wang; Longshan Zhao; Kaishun Bi; Xiaohui Chen;
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作者单位

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年(卷),期 2017(12),2
年度 2017
页码 -1
总页数 7
原文格式 PDF
正文语种
中图分类药学;
关键词
Methotrexate; Piperazine ferulate; Pharmacokinetic parameters; HPLC-MS;

机译：甲氨蝶呤;阿魏哌嗪;药代动力学参数;HPLC-MS;

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专利

1. Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS [J] . Huiyan Shi, Chenzhi Hou, Liqiang Gu, Asian Journal of Pharmaceutical Sciences . 2017,第2期

机译：HPLC-MS预处理阿魏酸哌嗪对甲氨蝶呤致肾损伤模型大鼠甲氨蝶呤药代动力学参数的影响
2. Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS [J] . Huiyan Shi, Chenzhi Hou, Liqiang Gu, 亚洲药物制剂科学(英文) . 2017,第002期

机译：阿魏酸哌嗪预处理对甲氨蝶呤致肾损伤模型大鼠甲氨蝶呤药代动力学参数的影响
3. Carvacrol prevents methotrexate-induced renal oxidative injury and renal damage in rats [J] . Bozkurt Mehtap, Em Serda, Oktayoglu Pelin, Clinical and investigative medicine: Medecine clinique et experimentale . 2014,第1期

机译：香芹酚可预防甲氨蝶呤引起的大鼠肾脏氧化损伤和肾脏损害
4. A Physiologically-Based Pharmacokinetic Model of Methotrexate Incorporating Hepatic Excretion via Multidrug-Resistance-Associated Protein 2 (Mrp2) in Mice, Rats, Dogs, and Humans [C] . Manupat Lohitnavy, Yasong Lu, Ornrat Lohitnavy, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2017

机译：通过小鼠，大鼠，狗和人类，通过多药抗性相关蛋白2（MRP2）掺入肝细胞排泄的生理学上的药代动力学模型
5. Developing patient specific population pharmacokinetic models and comparing compartmental vs. non-compartmental analysis for the prediction of individual pharmacokinetic parameters. [D] . Hines, Daniel Joseph. 2009

机译：开发患者特定人群的药代动力学模型并比较隔室与非隔室分析，以预测各个药代动力学参数。
6. Ginkgo Biloba Extract Alleviates Methotrexate-Induced Renal Injury: New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression [O] . Iman O. Sherif, Nora H. Al-Shaalan, Dina Sabry 2019

机译：银杏叶提取物减轻了甲氨蝶呤引起的肾损伤：对PI3K / Akt / mTOR信号和MALAT1表达的新影响
7. Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS [O] . Huiyan Shi, Chenzhi Hou, Liqiang Gu, 2017

机译：高效液相色谱 - 质谱法预处理阿魏酸哌嗪对甲氨蝶呤致肾损伤模型大鼠甲氨蝶呤药代动力学参数的影响

Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

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