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The effect of intravenous human adipose–derived stem cells (hADSC) on transforming growth factor β1 (TGF-β1) collagen type 1 and kidney histopathological features in the unilateral ureteropelvic junction obstruction model of wistar rats

机译：wistar大鼠单侧输尿管盆腔阻塞模型中静脉内人脂肪干细胞（hADSC）对转化生长因子β1（TGF-β1）1型胶原和肾脏组织病理学特征的影响

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The fibrotic process of kidney resulting in glomerulosclerosis was found in patients with ureteropelvic junction obstruction (UPJO) who underwent renal biopsy during pyeloplasty. Transforming growth factor β1 (TGF-β1) plays a role in collagen accumulation, resulting in fibrosis. Adipose tissue–derived stem cells (ADSCs) have an anti-apoptotic effect on target cells and enhance the kidney function recovery. We will further investigate the use of ADSC in the prevention of kidney fibrosis in the unilateral UPJO model of Wistar rats.

机译：在肾盂成形术期间接受肾活检的输尿管盆腔连接梗阻（UPJO）患者中发现了导致肾小球硬化的肾脏纤维化过程。转化生长因子β1（TGF-β1）在胶原蛋白积累中起作用，导致纤维化。源自脂肪组织的干细胞（ADSC）对靶细胞具有抗凋亡作用，并增强了肾功能的恢复。我们将进一步研究在Wistar大鼠单侧UPJO模型中ADSC预防肾脏纤维化的用途。

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期刊名称 Turkish Journal of Urology
作者
Safendra Siregar; Bambang Sasongko Noegroho; Muhammad Ilhamul Karim;
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作者单位

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年(卷),期 2020(46),3
年度 2020
页码 -1
总页数 7
原文格式 PDF
正文语种
中图分类泌尿科学（泌尿生殖系疾病）;小儿泌尿科学;肾疾病;
关键词
Collagen type I; stem cells; TGF-β1; ureteral obstruction;

机译：Ⅰ型胶原;干细胞;TGF-β1;输尿管阻塞;

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1. Effect of Intracorporeal Human Adipose–Derived Stem Cells (hADSCs) on Corpora Cavernosa Transforming Growth Factor β1 (TGFβ1) and Collagen Type I Concentration in Wistar Rat Priapism Model [J] . Safendra Siregar, Ricky Adriansjah, Jupiter Sibarani, Research and Reports in Urology . 2020,第1期

机译：体内人脂肪衍生的干细胞（HADSCs）对Wistar大鼠Priapism模型中Corea Cavernosa转化生长因子β1（TGFβ1）和胶原型I浓度的影响
2. Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with human disc cells stimulate proteoglycan and collagen type I rich extracellular matrix [J] . Hazel Tapp, Ray Deepe, Jane A Ingram, Arthritis Research . 2008,第4期

机译：来自沙鼠的脂肪来源的间充质干细胞：转化生长因子β和3D与人圆盘细胞的共培养刺激蛋白聚糖和富含I型胶原的细胞外基质
3. Congenital unilateral ureteropelvic junction obstruction of the rat: a useful animal model for human ureteropelvic junction obstruction? [J] . Miller J, Hesse M, Diemer T, Urology . 2004,第1期

机译：大鼠先天性单侧输尿管盆腔连接阻塞：有用的人输尿管盆腔连接阻塞动物模型吗？
4. Human urine-derived stem cells expressing vascular endothelial growth factor within collagen type Ⅰ gels promote muscle and nerve regeneration in vivo [C] . Guihua Liu, Shaofeng Wu, Shantaram Bharadwaj, World biomaterials congress . 2012

机译：Ⅰ型胶原凝胶中表达血管内皮生长因子的人尿干细胞在体内促进肌肉和神经再生
5. Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cell, but not Adipose Tissue-Derived Stem Cell, Ameliorated the Neonatal Hypoxic-Ischemic Brain Injury by Changing Cerebral Inflammatory State in Rat [D] . Sugiyama Yuichiro, 杉山裕一朗 2019

机译：静脉内施用骨髓源性间充质干细胞，而非脂肪组织源性干细胞，通过改变大鼠的脑炎症状态改善了新生儿缺氧缺血性脑损伤
6. Effect of Intracorporeal Human Adipose–Derived Stem Cells (hADSCs) on Corpora Cavernosa Transforming Growth Factor β1 (TGFβ1) and Collagen Type I Concentration in Wistar Rat Priapism Model [O] . Safendra Siregar, Ricky Adriansjah, Jupiter Sibarani, 2020

机译：Wistar大鼠多发性痴呆模型中人体内脂肪干细胞（hADSCs）对海绵体转化生长因子β1（TGFβ1）和I型胶原浓度的影响
7. The effect of intravenous human adipose–derived stem cells (hADSC) on transforming growth factor β1 (TGF-β1), collagen type 1, and kidney histopathological features in the unilateral ureteropelvic junction obstruction model of wistar rats [O] . Safendra Siregar, Bambang Sasongko Noegroho, Muhammad Ilhamul Karim 2020

机译：静脉内人脂肪衍生的干细胞（HADSC）对Wistar大鼠单侧输尿管尿布结梗阻模型转化生长因子β1（TGF-β1），胶原蛋白1型和肾组织病理学特征的影响
8. Platelet-derived Growth-factor-releasing Aligned Collagen-nanoparticle Fibers Promote the Proliferation and Tenogenic Differentiation of Adipose-derived Stem Cells. [R] . Cheng, X., Tsao, C., Sylvia, V. L., 2013

机译：血小板衍生的生长因子释放对齐胶原 - 纳米粒子纤维促进脂肪来源的干细胞的增殖和tenogenic分化。

The effect of intravenous human adipose–derived stem cells (hADSC) on transforming growth factor β1 (TGF-β1) collagen type 1 and kidney histopathological features in the unilateral ureteropelvic junction obstruction model of wistar rats

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