Chronic psychosocial stress during pregnancy affects maternal behavior and neuroendocrine function and modulates hypothalamic CRH and nuclear steroid receptor expression

摘要

Example of chronic psychosocial stress paradigm during pregnancy (CGS). Maternal body weight change from G6.5 - G17.5, Control = 17, CGS = 17. Raw maternal adrenal weights at PP2, Control = 20, CGS = 15. Maternal adrenal weight/body weight ratio at PP2, Control = 20, CGS = 15. Offspring body weight change from PN0 to PN21, Control = 17 litters, CGS = 17 litters. Data presented as mean + SEM. *  p t-test for differences in maternal body weight and adrenal weight, mixed linear ANOVA for offspring body weight analysis with stress x sex x day model and litter as a randomized block factor. G, gestational day; PP, postpartum day; PN, postnatal day.