NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma

摘要

Melanoma is a common skin cancer that is usually associated with poor clinical outcomes. Recently, the immune checkpoint GITR has been identified as a promising target for immunotherapy of melanoma. In this study, we aimed to investigate the post-translational regulation mechanism of GITR in melanoma.