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Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling

机译：OSR1的下调通过FAK介导的Akt和MAPK信号传导促进结肠腺癌的进展

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摘要

Odd-skipped related transcription factor 1 (OSR1) is a newly identified tumor suppressor in many tumor types. However, the role and mechanism of OSR1 in colon adenocarcinoma (COAD) remain unknown.

机译：跳过奇数相关转录因子1（OSR1）是在许多肿瘤类型中新近鉴定出的肿瘤抑制因子。但是，OSR1在结肠腺癌（COAD）中的作用和机制仍然未知。

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期刊名称 OncoTargets and therapy
作者
Fang Zhang; Zheng Jiang;
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作者单位

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年(卷),期 2020(13),-1
年度 2020
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类应用微生物学;肿瘤学;
关键词
OSR1; colon adenocarcinoma; tumor suppressor; FAK; Akt; MAPK;

机译：OSR1;结肠腺癌;肿瘤抑制因子;FAK;Akt;MAPK;

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专利

1. Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling [J] . Fang Zhang, Zheng Jiang OncoTargets and therapy . 2020,第2期

机译：OSR1的下调通过FAK介导的AKT和MAPK信号传导促进结肠腺癌进展
2. Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells [J] . CalvoN., MartínM.J., DeBolandA.R., Biochemistry and Cell Biology . 2014,第4期

机译：ERK1 / 2，p38 MAPK和PI3K / Akt信号通路参与PTHrP调节结肠腺癌细胞的细胞周期进程
3. Kindlin-2 induced by TGF-beta signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9 [J] . Zhan Jun, Song Jiagui, Wang Peng, Cancer letters . 2015,第1期

机译：TGF-β信号转导的Kindlin-2通过下调转录因子HOXB9促进胰腺导管腺癌的进展
4. Simulations of the EGFR - KRAS - MAPK Signalling Network in Colon Cancer. Virtual Mutations and Virtual Treatments with Inhibitors Have More Important Effects Than a 10 Times Range of Normal Parameters and Rates Fluctuations [C] . Nicoletta Castagnino, Lorenzo Tortolina, Roberto Montagna, International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics . 2010

机译：EGFR - KRAS - MAPK信号网络在结肠癌中的模拟。具有抑制剂的虚拟突变和虚拟处理具有比正常参数范围的10倍的更重要的效果和速率波动
5. The effects of a purified B-group soyasaponin fraction on the proliferation, cell cycle progression and induction of macroautophagy in HCT-15 human colon adenocarcinoma cells. [D] . Ellington, Allison Ann. 2005

机译：纯化的B组大豆皂苷组分对HCT-15人结肠腺癌细胞增殖，细胞周期进程和诱导巨自噬的影响。
6. Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells [O] . Chung-Weng Phang, Saiful Anuar Karsani, Gautam Sethi, -1

机译：Flavokawain C抑制细胞周期并促进凋亡与内质网应激以及HCT 116人结肠癌细胞中MAPK和Akt信号通路的调节有关。
7. Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. [O] . Chung-Weng Phang, Saiful Anuar Karsani, Gautam Sethi, 2016

机译：Flavokawain C抑制细胞周期并促进细胞凋亡，与内质网应激相关，并调节HCT116人结肠癌细胞中mapKs和akt信号通路。

Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling

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