Hepatocyte gene expression and DNA methylation as ancestry-dependent mechanisms in African Americans

摘要

Flowchart outlining each cohort use in the analyses. Hepatocyte Discovery Cohort from AA primary hepatocyte cultures were RNA-sequenced and assessed for DNA methylation. The GTEx Liver Replication Cohort was comprised of AA liver samples with available genotype and gene expression data. Innocenti Liver Validation Cohort was comprised of liver samples from both EAs and AAs obtained through GEO (accession ), in which differential gene expression was used to validate findings from the Hepatocyte Discovery Cohort