Identification of STAB1 in Multiple Datasets as a Prognostic Factor for Cytogenetically Normal AML: Mechanism and Drug Indications

摘要

Cytogenetically normal acute myeloid leukemia (CN-AML) presents with diverse outcomes in different patients and is categorized as an intermediate prognosis group. It is important to identify prognostic factors for CN-AML risk stratification. In this study, using the TCGA CN-AML dataset, we found that the scavenger receptor stabilin-1 ( ) is a prognostic factor for poor outcomes and validated it in three other independent CN-AML datasets. The high expression ( ) group had shorter event-free survival compared with the low expression ( ) group in both the TCGA dataset (n = 79; p = 0.0478) and GEO: dataset (n = 187; p = 0.0354). Differential expression analysis between the and groups revealed that upregulated genes in the group were enriched in pathways related to cell adhesion and migration and immune responses. We confirmed that suppression inhibits cell growth in KG1a and NB4 leukemia cells. Expression correlation analyses between and cancer drug targets suggested that patients in the group are more sensitive to the BCL2 inhibitor venetoclax, and we confirmed it in cell lines. In conclusion, we identified as a prognostic factor for CN-AML in multiple datasets, explored its underlying mechanism, and provided potential therapeutic indications.