Role of Jumpstart Nutrition® a Dietary Supplement to Ameliorate Calcium-to-Phosphorus Ratio and Parathyroid Hormone of Patients with Osteoarthritis

摘要

The aim of this study was to use Jumpstart Nutrition bone supplementing combination with vitamin-K and coenzyme-Q characterized by an innovative delivery system that improves bioavailability of calcium-to-phosphorus ratio (CPR) and parathyroid hormone (PTH) in the management of osteoarthritis (OA). This eight-week registry included 108 patients treated for symptomatic OA confirmed with radiological images. On top of that, 63 patients used Jumpstart Nutrition supplement, mainly prepared with calcium, phosphorus, coenzyme-Q , vitamin-K , vitamin-D , vitamin-C, folic acid, curcumin and boswellic acids. Rescue medication was also recommended. Patients’ pain and functional capacity through outcome measures—knee-injury osteoarthritis outcome scale (KOOS) and Karnofsky performance scale (KPS), biomarkers such as levels of CPR, PTH and 25-hydroxy-vitamin-D were evaluated for the groups with and without supplement using appropriate kits. After eight weeks, the levels of CPR and PTH were all significantly improved ( < 0.001), fewer subjects had to use rescue medication ( < 0.05) and variation of pain and functional capacity under KOOS and KPS ( < 0.05) of the patients in the supplement group compared to controls. This registry study indicates that Jumpstart Nutrition can be used safely for effective management of OA patients for the amelioration of CPR, PTH and functional activities confirmed with biomarkers and radiological images correlated with the Kellgren-Lawrance scale.