To perform a systematic review and meta-analysis with the aim of determining the relationship between infection and psoriasis. : Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Web of Science were searched for articles published up to July, 2019. Review Manager 5.3 and Stata 12.0 were used for statistical analyses. : The initial database search resulted in 204 articles. Through exclusion and screening, 11 studies involving a total of 1741 participants were finally included in this meta-analysis. The odds ratio (OR) of infection rate in the psoriasis group was significantly higher than that in the control group (OR = 1.19, 95% CI 1.15–2.52, = 0.008). Subgroup analysis showed that no significant difference was detected between the Asia group and the Europe group. As for the methods of detection, a statistically significant increase of infection in the IgG ELISA test group was detected, compared with the urea breath test group. In addition, analysis based on the severity of psoriasis showed a statistically significant increase of infection in moderate and severe psoriasis patients (OR = 2.27; 95% CI: 1.42–3.63, = 27%), but not in the mild psoriasis patients (OR = 1.10; 95% CI: 0.79–1.54, = 0%). : infection is associated with psoriasis, and psoriasis patients with infection have higher Psoriasis Area and Severity Index (PASI) scores. The findings are of considerable significance for the clinical practices.
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