Mutations analysis of BRCA1 gene in patients with breast cancer in South Khorasan province East Iran

摘要

Breast cancer (BC) is well-known as the most common malignancy and the first leading cause of cancer-related death among women worldwide. Evidence suggests that familial history and age are important risk factors for the development of this disease in Iran. Mutations in and genes are the cause of 5 to 10% of hereditary BC. Recent studies demonstrated that mutations in were observed in high-risk women with family histories of BC. However, to date, the mutations have not been elucidated in BC patients from east of Iran. The purpose of this study was to analyze mutations in BC patient from South Khorasan Province.