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Fast assignment of adequate neoadjuvant chemotherapy for breast cancer patients based on the identification of constitutional BRCA1 mutations
Fast assignment of adequate neoadjuvant chemotherapy for breast cancer patients based on the identification of constitutional BRCA1 mutations
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机译:基于结构性BRCA1突变的鉴定,为乳腺癌患者快速分配适当的新辅助化疗
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摘要
Disclosed is a method and composition for optimizing the efficiency of breast cancer neoadjuvant chemotherapy, depending on the particular constitutional genotype characteristics of the gene BRCA1 in each patient. Generally, the invention concerns a new method to improve neoadjuvant therapy depending on a particular constitutional genotype. Subject of invention allow to synthesize DNA and identification of germline BRCA1 genetic abnormalities which are correlated with a significantly decreased clinical response to neoadjuvant chemotherapy based on taxane-derived cytostatics in breast cancer patients.
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